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Buffalo opened the season with a pair of blowout wins over the Rams and Titans, but has played a pair of close games since then. The Bills came up just short at Miami in Week 3 before sneaking past the Ravens in a 23-20 final last week. They will try to return to dominant form when they host Pittsburgh during the Week 5 NFL schedule. Buffalo is a 14-point favorite in the latest Week 5 NFL odds at Caesars Sportsbook, while the over/under is 47. Elsewhere in the AFC, the Colts will be without star running back Jonathan Taylor (ankle) on Thursday Night Football, so should you include the Broncos in your Week 5 NFL bets to cover as 3.5-point favorites? Which Week 5 NFL lines should you target with your Week 5 NFL bets? Before you make any Week 5 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 5. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 5 NFL picks at SportsLine.

Top Week 5 NFL picks

After simulating every game 10,000 times, the model is high on the Miami Dolphins (-3) to win and cover against the New York Jets on Sunday. The Dolphins will likely be without quarterback Tua Tagovailoa on Sunday due to a head injury, but they have one of the best backups in the NFL in Teddy Bridgewater. He threw for 193 yards and a touchdown in relief of Tagovailoa at Cincinnati last week and has an ideal matchup against a struggling New York defense this week.

The Jets rank No. 27 in points allowed per game (25.3), while Miami’s offense is ninth in scoring (24.5). Miami has dominated this series over the past four years, winning and covering the spread in seven of the last eight meetings. The Dolphins have also won 11 of their last 13 games overall, while New York has only picked up one win in its last eight home games. SportsLine’s model has Miami covering the spread in well over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 5 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog to win outright. You can only see the model’s NFL Week 5 best bets and parlay at SportsLine.

What are the model’s top Week 5 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 5 NFL best bets from a model on a 139-103 run on its top-rated picks, and find out.

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