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Nathaniel Hackett and the Denver Broncos (2-3) will battle Brandon Staley and the Los Angeles Chargers (3-2) in a primetime affair on Monday Night Football. Both squads want this win badly, so we can expect a high-energy contest to close out the Week 6 NFL schedule. The Broncos are 12-4 against the spread in their last 16 games after scoring fewer than 15 points in their previous game. Meanwhile, the Chargers are 8-3 against the spread in their last 11 games versus the AFC West.

Kickoff is at 8:15 p.m. ET in Los Angeles. Caesars Sportsbook lists Los Angeles as the 4.5-point home favorite, while the over/under, or total number of points Vegas thinks will be scored, is 45.5 in the latest Broncos vs. Chargers odds. Before locking in any Chargers vs. Broncos picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Chargers and just locked in its picks and MNF predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and betting lines for Chargers vs. Broncos:

  • Broncos vs. Chargers spread: Chargers -4.5
  • Broncos vs. Chargers over/under: 45.5 points
  • Broncos vs. Chargers money line: Chargers -220, Broncos +180
  • DEN: Broncos are 1-4 against the spread this season
  • LAC: Chargers are 4-1 against the spread this season
  • Broncos vs. Chargers picks: See picks at SportsLine

Featured Game | Los Angeles Chargers vs. Denver Broncos

Why the Broncos can cover

Los Angeles is in the bottom 10 of the NFL in rushing yards this season and is averaging only 3.6 yards per carry. Los Angeles is also below average in both third down conversion rate (39.1%) and red zone efficiency (52.1%), and Denver enters Week 6 with one of the NFL’s best defensive profiles. The Broncos allowed only 12 points in an overtime game last week, generating six sacks and stifling the Colts’ offense. Denver leads the NFL in passing defense, yielding fewer than 180 yards per game, and is also atop the league in red zone efficiency allowed at 27.3%.

Denver is in the top five in points allowed (16.0 per game and 1.30 per drive) and yards allowed (289.0 per game and 25.5 per drive), with the Broncos pass rush putting pressure on opponents. Denver has a 36% pressure rate and a 9% sack rate, keyed in large part by former top-five pick Bradley Chubb. See which team to pick here.

Why the Chargers can cover

Los Angeles has an extremely talented secondary. Asante Samuel Jr. is an athletic and physical cornerback who makes plays on the ball. Samuel is third on the team in total tackles (21) and tied for first in pass deflections (four). Bryce Callahan is another stout cornerback. He may be undersized (5-foot-9), but he’s very instinctive and has a nose for the ball. The Rice product has logged 16 total tackles with four pass deflections and a team-best two interceptions.

J.C. Jackson rounds out this starting cornerback group. Jackson is exceptional in man coverage with ball-hawking skills. The Maryland product can quickly change directions and break on the ball in a hurry. He’s recorded 10 stops and one pass deflection through three games. See which team to pick here.

How to make Broncos vs. Chargers picks

SportsLine’s model is leaning Over on the point total. In fact, it’s calling for 47 combined points. It also says one of the spread has all the value. You can only get the model’s MNF picks at SportsLine.

So who wins Chargers vs. Broncos on Monday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Chargers vs. Broncos spread to jump on, all from the advanced model that is up nearly $7,000 on its NFL picks, and find out.

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